Multiple Endocrine Neoplasia in Childhood: An Update on Diagnosis, Screening, Management and Treatment

Multiple endocrine neoplasia (MEN) is a group of heterogenous syndromes characterized by the occurrence two or more gland tumors in patient related individuals same family. They are inherited an autosomal dominant fashion and highly penetrant. There three types MEN syndromes: type 1 (MEN1), 2 (MEN2), 4 (MEN4). MEN2 further divided into MEN2A, MEN2B (formerly known MEN3), familial medullary thyroid carcinoma (FMTC). Although rare, it crucial to identify at risk for potentially life-threatening neoplasias. This review article provides update on each syndrome, its genetics, diagnosis, management children.